Sanford-Burnham Medical Research Institute (Sanford-Burnham) has entered into a collaboration with Ortho-McNeil-Janssen Pharmaceuticals, Inc., (OMJPI) to discover compounds for Alzheimer?s disease and major psychiatric disorders. Under the agreement, multi-disciplinary teams from Sanford-Burnham and OMJPI will collaborate to identify and validate new targets for drug discovery and will seek compounds suitable for lead optimization and further development by OMJPI.

OMJPI gains exclusive access for a three-year term to a multi-disciplinary team of world-class scientists and a translational infrastructure dedicated to finding new approaches to treating patients with devastating neurological and psychiatric conditions.

For Sanford-Burnham, the collaboration with researchers at a major pharmaceutical company will help the Institute achieve its mission of translating high-impact science into important new therapies. ?This represents the first of what we expect to be a series of thematic collaborations that focus our tremendous scientific and translational firepower on major unmet medical problems. Working in concert with strong partners, we can bridge the gap between early- and late-stage drug development,? said Dr. John Reed, CEO of Sanford-Burnham.

Sanford-Burnham will also receive funding including: upfront and yearly access fees, funding of discovery research in the field, milestone payments and royalties for successfully developed products. A joint steering committee will oversee the collaboration, which includes a drug discovery team funded by OMJPI in the Conrad Prebys Center for Chemical Genomics (CPCCG) at Sanford-Burnham.

CPCCG is Sanford-Burnham?s state-of-the-art screening facility established by the National Institutes of Health as part of a national effort to accelerate the rate of commercialization of basic research by generating small molecule probes that can be used to develop a pipeline of drugs to treat unmet medical needs. Sanford-Burnham?s drug discovery capabilities include: ultra high-throughput screening; high content screening; phenotypic screening; and target deconvolution technologies. CPCCG is led and staffed by industry-trained professionals who work closely with Sanford-Burnham investigators and industry collaborators to assist them in translating their scientific findings into actionable projects for new drug discovery.

?This agreement sets the stage for Sanford-Burnham to fully leverage the drug discovery infrastructure the Institute has put into place over the last five years,? said Dr. Michael Jackson, Vice President, Drug Discovery and Development at Sanford-Burnham.

Alzheimer?s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. Recent estimates from the Alzheimer?s Association put the number of people in the U.S. with Alzheimer?s at 5.3 million. While four drugs that temporarily improve cognitive function in Alzheimer?s patients are on the market, currently, there is no treatment available to stop the progression of Alzheimer?s disease.

Major psychiatric disorders, such as bipolar disorder, major depressive disorder and schizophrenia, are a huge burden on society. These conditions have their onset in adolescence or early adulthood, and impair overall health as well as the ability to learn, work and function in society. According to the National Institute of Mental Health 2.3 million adult Americans suffer from bipolar disorder, a condition associated with profound alterations of mood. Similar to other chronic health conditions, such as diabetes or heart disease, bipolar disorder and other major psychiatric illnesses must be treated and managed throughout a person?s life.

About Sanford-Burnham Medical Research Institute

Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham, with operations in California and Florida, is one of the fastest-growing research institutes in the country. The Institute ranks among the top independent research institutions nationally for NIH grant funding and among the top organizations worldwide for its research impact. From 1999 ? 2009, Sanford-Burnham ranked #1 worldwide among all types of organizations in the fields of biology and biochemistry for the impact of its research publications, defined by citations per publication, according to the Institute for Scientific Information. According to government statistics, Sanford-Burnham ranks #2 nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded.

Sanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a nonprofit public benefit corporation. For more information, please visit http://www.sanfordburnham.org.

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It’s nearly summer, time for a trip to the beach, the mountains, or beyond. Wherever you’re vacationing, some advance planning will help ensure you have a healthy trip. Before you travel, here is what to do:

Before you hit the road, gets a letter from your doctor explaining how you take care of your diabetes. If you use insulin or any other medications or lancing devices, it should list them. In case of emergency, you should also have a prescription for insulin or oral medication.

Are you traveling outside the U.S.? Be aware that prescription laws may be different in other countries than they are in the U.S. You can get a list of International Diabetes Federation groups from www.idf.org.You may also want to get a list of English-speaking doctors in the country or countries you plan to visit. Contact the International Association for Medical Assistance to Travelers at www.iamat.org.

Pack at least twice as much medication and glucose-testing equipment (diabetes test strips, glucose test meters, body fat weight scale and monitors etc) as you expect to need. Have a carry-on bag with you at all times that contain:

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• Your insulin and testing supplies • Extra batteries for your diabetic glucose meter • All oral medications • Your ID and diabetes identity card • An air-tight snack pack of crackers or cheese, peanut butter, fruit, a juice box, and hard candy or glucose tablets

When flying, you can request a special meal or diabetic diet meals; check with your airlines to find out how much in advance you need to do this. If you use insulin, wait until you see your diabetic meals coming before you give yourself an injection so a delay doesn’t result in low blood sugar. To be safe, always carry some food with you.

Think about where you’ll store your insulin. It doesn’t have to be refrigerated, but storing it somewhere hot, such as in the glove compartment, or somewhere very cold, on ice, for example, can cause it to lose strength. Look for a travel pack that keeps insulin cool.

If you use insulin and plan to travel to another time zone, consult with your doctor or diabetes educator before you leave. If you’re heading east, you’ll have a shorter day, meaning you may need less insulin; if you go west, the longer day may mean you’ll need more insulin.

When you reach your destination, especially if you’ve had a long trip, take it easy for a few days. Check your blood sugar often with blood sugar monitors. When you’re out seeing the sights, wear comfortable diabetics shoes and don’t go barefoot. Check your feet daily for blisters, scratches, or redness, and seek medical care at the first sign of any of these.

Make taking care of your diabetes a priority on your travels and you’ll be rewarded with a fun and healthy vacation. Bon voyage!

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