Tag Archives: Parkinsons

Latest Parkinsons News

Island race is no fantasy for Natalie's pals
A DAUGHTER is following in the footsteps of her fitness fanatic mum who launched a charity after her husband developed Parkinson's. Tweet. Custom byline text: By RACHEL LOXTON. Natalie Antonelli has organised a run to support Michael's Movers, which
Read more on Glasgow Evening Times

Parkinson's group names Plum couple local heroes
Tom and Carol Reid of Plum began their journey to help people with Parkinson's disease 15 years ago. Mr. Reid was an in-house attorney for Koppers Co. Inc. in Pittsburgh, when he began to have symptoms of Parkinson's, such as drooling and watering
Read more on Pittsburgh Post Gazette

Healthy Living: Parkinson's Disease
"It is recognized that people with Parkinson's may have memory problems, but the patterns of it are different then the memory patterns that you see with people with Alzheimer's,” said Dr. Storey. There is no cure. Treatment options include drugs that
Read more on YNN, Your News Now

Restoring a Classic Dodge Over Six Decades Forges a Lifeline for an Artist With Parkinson’s Disease.


Bellingham, WA (PRWEB) February 29, 2012

A man restoring life, glory, and spirit to an aging, abandoned automobile isn’t unusual. In “The Dodge: Guts, Glory, and Living at Full-Throttle,” though, it is almost mystical how one 1941 Dodge D-19 Luxury Liner convertible snagged Mike’s 17-year-old’s heart and is still in his life sixty years later, filling a remarkable role. They’ve both weathered life’s many passages — even the assaults on his quality of life and emerging disabilities from Parkinson’s disease; she, abandonment and deterioration when he goes off to war.

Award-winning potter and sculptor and lifelong auto collector and restoration enthusiast, Eduard Alden ?Mike? Mikkelsen, collaborated on this new memoir (February 2012) with his wife, Anne Cutter Mikkelsen. Anne, a French trained chef, Master Gardener, writer ? and carepartner to Mike ? also is the author of ?Take Charge of Parkinson?s Disease: Dynamic Lifestyle Changes to Put You in the Driver’s Seat,? which shares how the couple has learned to live vibrantly with PD since his 1993 diagnosis. Now, ?The Dodge? recounts the intertwined life stories of Mike, Anne, and the beloved automobile, which seems to come to life each time they need her most. Together, they share a valuable message about the loss of control underscoring PD and other neurodegenerative disease: Make the most of what we can control ? how we choose to think about our circumstances and what we bring to our relationships.

From the authors — who live in Bellingham, WA and have deep roots in Minnesota — about “The Dodge: Guts, Glory, and Living at Full-Throttle”:

It was love at first sight. Mike, a 17-year old Lewistown, Montana cowboy, wanted to own the 1941 Dodge D-19 Luxury Liner convertible. She sat, neglected and alone,with a prickly bale of hay on her backseat.????

Two years after driving the Dodge home to Montana, Mike had to leave her when he went to war. Eventually she found herself at the bottom of a Montana coulee. Twenty years passed, a tree grew through her body and wild flowers flowed from her glovebox. She almost gave up hope of ever seeing him again.

Meanwhile a silent invader was taking root inside Mike forcing him down into his own pit.

Set on forty acres outside Northfield, Minnesota, the car/man journey of renewal and rebirth folds Mike?s lifelong passion for cars into his wife, Anne?s love of food, plants and children. While Anne, a French-trained chef, provides peace and sustenance for guests at her country B&B, Mike, an artist of clay and metal, juggles a robust auto restoration business in the basement of the garage with a pottery and sculpture studio upstairs. Life at full-throttle.

As Parkinson?s disease threatens to alter the couple’s lifestyle, the Dodge comes to life adding a powerful ingredient to their Quality of Life recipe. This story of perseverance, love and commitment is not just a tale of restoring a beloved “rolling sculpture.” For Mike and the Dodge, the creation and evolution of their magical bond ultimately provides a life-line for both.

Read an excerpt from “The Dodge.”

About “Take Charge of Parkinson’s Disease”: The personal story of how she and Mike learned to live vibrantly since his 1993 PD diagnosis. Presents information on re-focused nutrition, exercise, and healthy emotional coping strategies that may play roles in maintaining optimal health while living with Parkinson’s disease and other neurodegenerative disorders like multiple sclerosis.

A French trained chef, Master Gardener, and a former restaurateur and bed and breakfast proprietor, Anne presents more than 80 of her own original recipes and menus that combine a wide variety of anti-oxidant, anti-inflammatory, nutrient-rich ingredients, and culinary herbs and spices known to favorably impact the brain.

“The Dodge: Guts, Glory, and Living at Full-Throttle”

By Anne Cutter Mikkelsen and Eduard Alden Mikkelsen

Non-fiction, 264 pages

Paperback ISBN 978-0-983198222; ebook ISBN 978-0-983198215

Willow Island Press (2012)

Available at http://www.annecuttermikkelsen.com and http://www.Amazon.com.

“Take Charge of Parkinson’s Disease: Dynamic Lifestye Changes to Put You in the Driver’s Seat”

Named to “Top 20″ List of Small Press Titles Most in Demand from Libraries and Bookstores (Library Journal, March 1, 2012).

By Anne Cutter Mikkelsen and Carolyn Stinson

ISBN 13: 978-0-9823219-3-5

A DiaMedica Publishing Guide to Optimum Wellness (2011)

Available at http://www.annecuttermikkelsen.com, http://www.Amazon.com and in Bookstores

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“Take Charge of Parkinson’s Disease” Named to Top 20 In Demand List by Libraries and Bookstores


Baltimore, Md (PRWEB) February 29, 2012

“Take Charge of Parkinson’s Disease: Dynamic Lifestyle Changes to Put You in the Driver’s Seat” has been named to the Top 20 List of Books in Demand Nationwide by Libraries and Bookstores from Quality Books in the March 1, 2012 Library Journal. Number four on the list, “Take Charge” is an unusual how-to book for boosting physical and emotional resilience through brain healthy nutrition, exercise, and enlightened caregiving. More than 80 original recipes with the widest variety of anti-oxidant, anti-inflammatory, nutrient-rich ingredients, and culinary herbs and spices known to favorably impact the brain are presented by author Anne Cutter Mikkelsen, a French trained chef, Master Gardener, and carepartner to her husband Eduard Alden “Mike” Mikkelsen, an award-winning sculptor and potter, who was diagnosed with PD in 1993.

The Library Journal’s Top 20 List published on March 1, 2012, covers the six months prior to the week ending February 18, 2012. Library Journal, LLC is a wholly-owned subsidiary of Media Source, Inc.

Anne’s and Mike’s own stirring personal story of transcending the disease and living vibrantly provides the context for information about re-focusing nurition, developing healthy emotional coping strategies, risk factors, and research that points to potential neuroprotective and symptom management benefits afforded by certain types of exercise. The couple wishes to help cut the learning curve for others facing down a Parkinson’s disease diagnosis. “Take Charge” espouses making the most of what we can control: what we eat, how we choose to think about our circumstances, and what we bring to our relationships.

Read praise, reviews and excerpts.

“Take Charge of Parkinson’s Disease: Dynamic Lifestye Changes to Put You in the Driver’s Seat”

Anne Cutter Mikkelsen and Carolyn Stinson

ISBN 13: 978-0-9823219-3-5

A DiaMedica Publishing Guide to Optimum Wellness

(2011)

Available in paperback and e-book from Amazon.com, Bookstores, and at http://www.annecuttermikkelsen.com.

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Related Parkinsons Press Releases

MDS 15th International Congress of Parkinson’s Disease and Movement Disorders

TORONTO, ON, Can (PRWEB) May 31, 2011

The world?s leading experts in Parkinson?s disease and Movement Disorders will present the latest research findings and state-of-the-art treatment options at The Movement Disorder Society?s 15th International Congress of Parkinson?s Disease and Movement Disorders in Toronto, June 5-9, 2011.

The 15th International Congress, held at the Metro Toronto Convention Centre, will be attended by over 3,200 physicians, researchers and other healthcare professionals from 74 countries. Attendees will be able to view over 1,100 scientific abstracts submitted by clinicians from around the world. The International Congress Scientific Program consists of Plenary, Parallel, and Video Sessions, as well as Skills Workshops, Teaching Courses, and Guided Poster Tours.

Members of the media receive complimentary full-access registration to the Congress. For information on how to register, please view the MDS Press Information Web page. http://www.movementdisorders.org/congress/congress11/press.php

News Releases http://www.movementdisorders.org/congress/congress11/news_releases/

Read summaries of newsworthy research to be presented at the Congress.

Early dietary treatment of galactosemia is not enough to prevent development of movement disorders

Caffeine shown to influence age at onset in Huntington’s disease

Apathy is independent from depression and dementia in Parkinson’s disease

Inhaled apomorphine reduces “off” periods in Parkinson’s disease

Cycling ability maintained in Parkinson’s disease patients with freezing of gait

Polysomnographic findings in sleep disturbed Parkinson’s disease patients provide diagnostic and disease progression measurement tools

The LRRK2 G2019S mutation suggests Parkinson’s disease patients maybe predisposed to cancer

Safety and efficacy of octanoic acid in the treatment of essential tremor

15th International Congress Information

The International Congress section of the MDS website contains all the information you need to prepare for the meeting. http://www.movementdisorders.org/congress/congress11/

Final Program http://www.movementdisorders.org/congress/congress11/

MDS Press Policies, Press Room Information and Registration http://www.movementdisorders.org/congress/congress11/press.php

We look forward to seeing you in Toronto!

The Movement Disorder Society, an international society of over 3,000 clinicians, scientists, and other healthcare professionals, is dedicated to improving patient care through education and research. For more information about The Movement Disorder Society, visit http://www.movementdisorders.org.

Note: To receive additional materials or to register for the MDS 15th International Congress of Parkinson?s Disease and Movement Disorders, please contact Elizabeth Laur, elaur(at)movementdisorders(dot)org

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Study Reveals Top Non-genetic Risk Factors for Alzheimer?s and Parkinson?s, Reports DoctorsHealthPress.com


Boston, MA (PRWEB) July 10, 2012

The Doctors Health Press, a publisher of various natural health newsletters, books, and reports, including the popular online Doctors Health Press e-Bulletin, reports on an on-going study on the top risk factors of Alzheimer?s.

As reported in Doctors Health Press e-Bulletin (http://www.doctorshealthpress.com/brain-function-articles/the-top-risk-factors-for-alzheimers-revealed), over the past decade, medical professionals and scientists have been searching for any clues that show links between disease and environmental toxins. While some diseases are definitely caused by genetic factors, many others have simply baffled doctors. Alzheimer?s disease and Parkinson?s disease fall into this category. A lot has been learned about what happens when someone gets either of these medical conditions, but not a lot is known about what triggers them and causes them to take hold in the body in the first place.

The Doctors Health Press e-Bulletin article reports scientists generally agree that there is unlikely a single clear cause of Alzheimer?s. For this reason, many suggest Alzheimer?s is the result of a combination of inter-related factors, including genetic factors and environmental influences that could include anything from previous head trauma to educational level, to experiences early in life. A new growing body of research is also helping to identify various ?lifestyle factors,? such as dietary habits, high blood pressure, high cholesterol, and exposure to environmental toxins.

As for Parkinson?s, scientists know that the brain cells that control movement rely on a chemical called ?dopamine.? Dopamine is manufactured in an area of the brain called the substantia nigra. In Parkinson?s, dopamine-producing cells in the substantia nigra are lost. In most cases, no one knows why. Some genetic mutations have been discovered, suggesting that Parkinson?s may run in some families; however, new clinical trials are suggesting that environment plays a larger role than inheritance. In fact, the general medical consensus is that genetic factors are dominant only in Parkinson?s that appears before age 50.

So what?s really happening to usher in these two diseases? For some answers, consider the results from a recent clinical trial performed by Spanish researchers. These scientists decided to conduct a review to find which risk factors were most prominent when it came to Alzheimer?s or Parkinson?s. Here are the results, as the Doctors Health Press e-Bulletin article, ?The Top Risk Factors for Alzheimer?s Revealed,? reports:


????Evidence consistently suggests that a higher risk of Parkinson?s is associated with pesticides.
????A higher risk of Alzheimer?s is associated with pesticides, hypertension, high cholesterol levels in middle age, and high levels of homocysteine, smoking, traumatic brain injury, and depression.
????There is some evidence suggesting that higher risk of Parkinson?s is associated with high milk consumption in men, high iron intake, chronic anemia, and traumatic brain injury.
????There is also some evidence suggesting a higher risk of Alzheimer?s is associated with high aluminum intake through drinking water, excessive exposure to electromagnetic fields from electrical grids, obesity in middle age, excessive alcohol consumption, and chronic anemia.

(SOURCE: Campdelacreu, J., “Parkinson disease and Alzheimer disease: environmental risk factors,” Journal Neurologia, June 13, 2012.)

Doctors Health Press e-Bulletin is a daily e-letter providing natural health news with a focus on natural healing through foods, herbs and other breakthrough health alternative treatments. For more information on Doctors Health Press, visit http://www.doctorshealthpress.com.

The Doctors Health Press believes in the healing properties of various superfoods, like pistachios, as well as the benefits of taking vitamins and supplements, Chinese herbal remedies and homeopathy. To see a video outlining the Doctors Health Press’ views on homeopathic healing, visit http://www.doctorshealthpress.com/homeopathy.







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Trivantis Executive Retires to Become Leading Fundraiser for Parkinson?s Disease and Advocate for a Healthy Lifestyle


Cincinnati, Ohio (PRWEB) August 29, 2011

Former Executive Vice President of Trivantis, Ben Contra, Jr., retires to achieve his personal goal to become one of the top fundraisers for Parkinson?s Disease both in the Greater Cincinnati area and nationally. After two-and-a-half years of sharing the news of his diagnosis solely with his wife, Contra decided to break his silence this past July and step down from his leadership role with Trivantis to focus his time and attention on fighting Parkinson?s disease.

“My personal struggle with Parkinson’s Disease has just begun, but I know the support of those around me will help me persevere,” said Contra. “I know I am not alone and will make it my mission to raise awareness and help find a cure for the millions that are affected by this disease.”

Contra plans to raise both money and awareness of the benefits of exercise and an active lifestyle and looks forward to working closely with the leading organizations dedicated to finding a cure and improving care for patients: National Parkinson Foundation, the American Parkinson Disease Association, Parkinson?s Disease Foundation, Davis Phinney Foundation, and the Michael J. Fox Foundation.

Prior to his diagnosis, Contra spent nine years helping Trivantis evolve as a leader in the e-Learning industry. With overwhelming encouragement pouring in from extended family, Trivantis customers, board members, employees and investors, Contra is confident his mission will be a success.

To look at 49-year-old Ben Contra, you would never guess he suffers from a degenerative disease that affects 1.5 million Americans, the majority of which are over the age of 60. A marathoner who exercised religiously seven days a week, Contra was shocked when his doctors informed him two and a half years ago that the stiffness and tremors he was experiencing were symptoms of early-onset Parkinson?s disease.

His journey has not been easy. With three children, a loving supportive wife at home and a long, successful career with Trivantis ahead of him, having Parkinson?s was difficult for Contra to accept. Dealing with ongoing denial, anger and fear made the struggle even more challenging. The decision to step down and announce retirement and Parkinson?s to the world after two and a half years of total silence was difficult to reach. The daily annoyances of the disease were gradually becoming too overwhelming to keep pace at the level of perfection that Contra demanded of himself. As the news spread throughout the company and the community, tears of concern turned into an outpouring of love and support. Contra was amazed at the amount of thoughtful letters he received from not only his friends, colleagues, customers, and partners, but from casual acquaintances too. With this outpouring of encouragement and support, he has been able to weather the initial shock and denial of his condition and is grateful that he has gone public with his disease.

Contra knows all too well the widespread misconception that Parkinson?s disease affects only the elderly. But according to the American Parkinson Disease Association?s National Young Onset Center, ??about 10%-20% of those diagnosed with Parkinson’s disease are under age 50, and about half of those are diagnosed before age 40.? A degenerative disorder of the central nervous system, Parkinson?s disease can manifest itself in a multitude of symptoms, all of which can be exacerbated by even the simplest of daily tasks.

For others with early-onset Parkinson?s disease, however, the road to acceptance is still an uphill battle. But there are resources and support service available to patients. For instance, the National Young Onset Center provides an interactive guide to explore no-cost or low-cost resources and share experiences, resource recommendations and valuable feedback with others. The Michael J. Fox Foundation has a Guide for the Newly Diagnosed, and the National Parkinson?s Foundation has an extensive list of local chapters and support groups.

Even though no cure is currently available for Parkinson?s Disease, research is yielding significant results every day. And with a strong support team behind him and the courage to face his diagnosis head-on, Contra is confident he?ll emerge the winner in his battle with Parkinson?s disease.

Being driven and focused on exercise and nutrition, Contra is already assembling his first fundraising event, working on a joint event with the Davis Phinney Foundation and the Cincinnati Sports Mall. The 90-minute spin event is tentatively scheduled for November 19th at 6pm, whereby participants can reserve a bike for $ 100 and enjoy a party to follow the event starting at 8pm. Contra anticipates a sold out event once the event is finalized and marketed.

You can join Ben?s Facebook Group titled Support Ben Contra in his Parkinson?s battle. He has amassed over 300 supporters to his cause in the last few weeks and will communicate to his supporters on a quarterly basis.

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American Parkinson Disease Assoc. LA Chapter and Sandy Milken Present: The 2012 Parkinson’s Beach Brigade Walk-a-thon & Health Expo on Sunday, April 29 in Santa Monica, CA


Los Angeles, CA (PRWEB) March 12, 2012

April is Parkinson’s Disease Awareness Month and the LA chapter of the American Parkinson Disease Association has announced its annual Parkinson’s Beach Brigade Walk-a-thon and Health Expo. The event will be held at the Santa Monica City Hall on Sunday, April 29th from 9 am until noon, and is part of a national fundraising effort supporting scientific research for a cure.

“This year’s event will be our biggest one yet,” commented Nessa Weinman, Director APDA LA chapter. “Walkers and teams are registering and we have great sponsors on board. We also have support from the Michael J. Fox Foundation, and a lot of interest from celebrities and community leaders that support finding a cure for this devastating disease.”

The APDA LA has spokespersons available for interviews and appearances. To arrange, please contact Elisabeth Hinckley at 310 528 6919 or eah_pr(at)att(dot)net.

Parkinson’s Beach Brigade Information

Sunday, April 29, 2012, from 9 am until noon

Registration begins at 9 am

Opening Ceremonies at 10 am

Walk begins at 10:30 am

Health Fair Expo & Photo Ops before and after the walk until noon

Santa Monica City Hall

1685 Main Street

Santa Monica, CA 90401

The walk is 2 miles along the gorgeous bluffs of Santa Monica and is wheelchair and walker accessible.

Register online here

Why Your Help Matters

Parkinson’s disease is a neuro-degenerative disorder that affects nearly 5 million people, some as young as 30 years old. Sufferers of this debilitating disease experience symptoms that include tremors, slowness of movement, a loss of balance, rigidity or freezing in place, softness of speech and depression.

About APDA LA

The National Parkinson Disease LA Chapter (APDA LA) is a nonprofit community-based organization dedicated to improving the quality of life of anyone affected by Parkinson’s disease. The organization brings together people with PD, loved ones and caregivers, providing support through a wide range of resources and events. APDA LA’s annual Parkinson’s Walk Beach Brigade raises funds to support scientific research for a cure. For more information, visit http://www.apdala.org.





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Audiology and Parkinson’s Institutes to Present New Medical Research on Parkinson’s Associated Fall Prevention at American Academy of Audiology Research Conference


Newport Beach, CA (PRWEB) March 15, 2012

Newport-Mesa Audiology, Balance and Ear Institute and The Parkinson?s and Movement Disorders Institute announced today they will present new medical research on vestibular dysfunction associated with Parkinson?s disease and the use of vestibular rehabilitation therapy to prevent falls at the AudiologyNOW! conference in Boston, March 28-31, 2012. The research session entitled ?Vestibular Dysfunction in Parkinson?s Disease? is scheduled on Wednesday, March 28, 2012 from 4 p.m. to 5 p.m. in Room: 257A at the Boston Convention and Exhibition Center.

According to the research abstract, ?Significant peripheral and central vestibular dysfunction was found in a group of nine Parkinson?s patients of which only a third of the abnormality would be detected with traditional ENG/VNG testing. With proper testing, identification of these abnormalities can be treated with vestibular rehabilitation therapy preventing falls, a major source of fatality in Parkinson?s disease.?

Research presenters and contributors include:

Cara Makuta, Au.D., Newport-Mesa, Audiology, Balance and Ear Institute
Howard Mango, Au.D., Ph.D., Newport-Mesa, Audiology, Balance and Ear Institute
Karen Frei, M.D., The Parkinson?s and Movement Disorders Institute
Daniel Truong, M.D., The Parkinson?s and Movement Disorders Institute (contributor)

According to Dr. Frei, imbalance and falls are commonplace in Parkinson?s disease. Loss of postural reflexes is one of the cardinal features of the disorder, however this tends to occur several years following the onset of symptoms. Complaints of imbalance and dizziness are common in Parkinson?s patients. The patients are often not clear when asked to describe their symptoms and many will state they ?feel as if they are going to fall.? Oftentimes, descriptions of their symptoms are similar to vertigo.

According to Dr. Makuta, significant peripheral and central vestibular dysfunction in these Parkinson?s patients was found. Traditional test standards identified vestibular weakness in 33 percent of these patients suggesting traditional test measures are insufficient to identify vestibular compromise. The abnormality found in more comprehensive testing reflects peripheral vestibular dysfunction. This data suggests a risk for vestibular weakness in Parkinson?s patients increasing their imbalance and risk of falling. Utilizing the appropriate diagnostic tools is critical for an appropriate diagnosis and it is important to implement vestibular rehabilitation therapy, which may provide improvement of balance and reduce fall risk.

Researchers noted, much more research in this area needs to be done to confirm these findings using larger numbers of patients.

About The Parkinson?s and Movement Disorders Institute:

Foremost, the physicians, research scientists and staff at The Parkinson?s and Movement Disorders Institute (http://www.pmdi.org) all share the common goal of providing superior care to our patients in the treatment of neurological disorders affecting movement. It is our belief that people who must cope with symptoms or illness have enhanced quality of life when they understand their diagnosis and treatment plan, and when they are informed and active participants in their own health care. We also know that we learn and improve as physicians from our experiences with all of our patients. In our clinical practice we encourage a relationship of open communication between patient and physician. 9940 Talbert Ave., Suite 204, Fountain Valley, CA 92708.

About Newport-Mesa Audiology Balance and Ear Institute:

Newport-Mesa Audiology, Balance and Ear Institute (http://www.dizziland.com) is one of the country?s leading institutes for the research, diagnosis, treatment and rehabilitation of patients with dizziness, vertigo and balance disorders. A team of doctors of audiology work with state-of-the-art technology in the areas of vestibular diagnosis and rehabilitation. The Institute is also one of the nation?s most well-equipped audiological facilities, serving an ever-growing number of adult, teen and pediatric hearing-loss cases. The Institute receives referrals from a broad network of physicians including neurologists, otolaryngologists, internal medicine, cardiologists and family physicians. 500 Old Newport Boulevard, Suite 101, Newport Beach, CA 92663. For more information, call (888) 371-3920.





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Rebirth from Parkinson’s Disease With Deep Brain Stimulation

Adelaide, South Australia (PRWEB) March 15, 2012

Sally Hunter shows how, by staying awake during surgery on his brain, Geoff Sykes recently regained some measure of normality, instead of severe Parkinson’s Disease.

Geoff Sykes may have contracted Parkinson’s from contact with a lead arsenate based sheep dip, on the farm, as a child. The sheep dunked him in the poisonous solution several times.

Scientists implicate pesticides as a cause of Parkinson’s because people who as children lived in areas where pesticides were sprayed, contract the illness more often than other people . People who live in rural areas also contract the illness earlier.

Heavy metals also cause neurological degeneration that mimics Parkinson’s. They act in the brain in the same way as the known causative pathways of Parkinson’s Disease. The connection here has not yet been proved, and more research need to be done on it.

As he grew up, Geoff was a larrikin, but rose to become a senior bank manager, and later a builder. In middle age, he was diagnosed with Parkinson’s Disease.

Eight years later he could barely cope. With his doctors, he was juggling his medication to try and feel OK. He had a mask-like face, lack of co-ordination of his body, dribbling from a corner of his mouth and involuntary writhing and twisting movements.

In desperation, and determination to get better, he accepted the offer of D.B.S. surgery. This involved staying awake while electrodes were inserted into his brain, so he could give feedback to the doctors. The electrodes were then attached to a stimulator, which is like a brain pacemaker.

When Geoff?s stimulator was switched on, his writhing and twisting movements stopped, he stood tall and was able to walk down the passage. Over time, although he had some side effects of the operation, to all intents and purposes he appeared normal.

There was great jubilation about Geoff?s new start due to Deep Brain Stimulation. He said he was ?as fit as a mallee bull?.

Sally Hunter?s website, http://www.sallyhunter.net.au, gives details of this book about Geoff?s journey. Commentators have described the book as wonderful, and it has been respectfully and beautifully written.

The website also gives more details about Sally, herself, and her other publications. She has a business in Environmental Writing, but does other kinds of writing as well.

Sally Hunter?s book is entitled You Can?t Keep a Good Man Down: From Parkinson’s to a New Life with Deep Brain Stimulation. It discusses Parkinson’s Disease and the last resort surgery, Deep Brain Stimulation, which can turn a sufferer?s life around. It is a biography of Geoff Sykes.

Sally Hunter has a science degree in biology and a Master?s degree in Environmental Studies. Her business in Environmental Writing also does other kinds of writing as well.

Sally Hunter, Environmental Writing, phone 618 8370 0365, http://www.sallyhunter.net.au, sally(dot)hunter(at)internode(dot)on(dot)net



BellBrook Labs? Novel RGScreen? Assay Technology is On Target for Parkinson?s Disease


Madison, WI (PRWEB) March 15, 2012

BellBrook Labs announced today that their RGScreen? Assay technology for detecting ?regulator of G-protein signaling? (RGS) protein activity, can be used to identify inhibitors of the RGS4 protein, which was identified in a groundbreaking new study as a promising target for Parkinson?s disease. The RGScreen? platform combines genetically engineered G proteins with BellBrook?s Transcreener? GDP Assay.

In a paper published last month in Neuron, investigators Anatol Kreitzer and Talia Lerner, at UCSF?s Gladstone Institute showed that knocking out the RGS4 protein, which normally helps regulate neural activity in the striatum, alleviated the aberrant motor control symptoms in dopamine-deficient mice used to model for Parkinson?s disease (Neuron 73:347-59). New therapeutic targets for Parkinson?s disease are badly needed, as the benefits of current drugs that act by increasing dopamine levels, or mimicking its effects, are almost always transient. The potential for developing drugs that target the RGS4 protein, and thus act by a completely different mechanism, is an exciting possibility that deserves exploration.

However, until very recently, efforts to screen for RGS protein inhibitors were largely unproductive, in part because there were no RGS protein assay methods for measuring functional activity that could be used in an HTS format. BellBrook scientists and collaborators in David Siderovski?s laboratory at the University of North Carolina School of Medicine recently overcame a longstanding hurdle to screening for inhibitors of RGS4 and other RGS proteins by developing proprietary G? protein variants that enable direct detection of RGS catalytic activity (J Biomol Screen 14:1195-206) using BellBrook?s Transcreener? GDP Assay. RGS proteins attenuate GPCR signaling by acting as “GTPase-accelerating proteins” (GAP) for G? proteins. The increased G? GTPase activity is undetectable in normal G? proteins, but it is unmasked by two synergistic mutations in BellBrook?s modified G? proteins. The RGS4 protein was used as a model for the BellBrook/UNC studies, thus the novel Parkinson?s disease target has already been validated for HTS in BellBrook?s RGScreen? assay.

BellBrook began providing the RGScreen? assay technology as a service in April of 2011, and has successfully developed and transferred assays to pharma partners interested in other RGS proteins; however, thus far none of them have been focused on the RGS4 protein. The company will soon offer a full line of RGS proteins and modified G? proteins for drug discovery and basic research focused on this exciting emerging target family.

About BellBrook Labs. BellBrook Labs, LLC develops detection reagents and microfluidic devices that accelerate the discovery of more effective therapies for cancer and other debilitating diseases. Transcreener? is a patented high throughput screening assay platform that was introduced in 2005 and is used to identify inhibitors for kinases and other types of protein drug targets. The iuvo? Microconduit Array technology and assay screening service is a line of unique microscale devices for miniaturization and automation of advanced cell models that are more representative of human physiology. Visit BellBrook?s website for more information: http://www.bellbrooklabs.com.





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