Chichester, West Sussex, UK (PRWEB) March 08, 2012
According to a new Espicom report, CNS Pipeline Fact Book 2012: What?s in Clinical Development, more than 270 agents are currently in Phases I, II or III clinical development for CNS indications. Around 37% of these are being developed for neurodegenerative conditions, particularly Alzheimer?s, which is the most common form of dementia. As progressively debilitating conditions, Parkinson?s disease and multiple sclerosis also fall into the neurodegenerative category. Another 30% of agents are being developed for pain indications; an area where the challenges faced by developers include difficult to treat conditions such as breakthrough cancer pain and neuropathic pain, as well as the need to tackle prescription drug abuse, which has reached epidemic proportions in the US.
Numerous companies are involved in CNS R&D, from small biotech companies focused on a single project to big pharma. Unsurprisingly, the vast majority of projects in the early clinical phases of development are being undertaken by biotech companies as big pharma continues to move away from costly R&D investment. Among the big pharma companies actively involved in the development of potential new therapies for CNS conditions, Pfizer is the most active, with direct involvement in 20 projects in clinical trials. Other major companies active in this area include GlaxoSmithKline, AstraZeneca, Biogen Idec, Sanofi, Merck & Co and Eli Lilly. However, fewer than 20 companies have five or more agents in clinical development for CNS conditions.
Over the last few years, the CNS sector has been characterised by multi-billion dollar blockbuster therapies, including Eli Lilly?s Zyprexa (olanzapine) and Cymbalta (duloxetine), Pfizer?s Lyrica (pregabalin) and Celebrex (celecoxib), AstraZeneca?s Seroquel (quetiapine fumarate), Teva?s Copaxone (glatiramer) and Bristol-Myers Squibb/Otsuka?s Abilify (aripiprazole). As their patents expire over the next few years, companies will face significant revenue losses. But with rising numbers of patients and significant unmet clinical need, there is a continued need for improved therapies in this sector.
Karen Holmes, senior market analyst at Espicom and the report?s author comments: ?the number of patients needing effective treatment for CNS conditions will continue to rise with the ageing population. While several major drugs will lose patent protection over the next few years, this sector seems to have a healthy pipeline of products that could keep the market buoyant for years to come.?
For further information on the report please visit http://www.espicom.com/cnsfbpr
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