Tag Archives: vascular

Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer?s Patients

Manhasset, NY (Vocus) February 6, 2009

People with a family history of Alzheimer?s disease, who have high levels of amyloid beta (A?) in the serum, are at increased risk for vascular disease. These heightened A? levels may predict whether those without symptoms may progress towards dementia in years to come.

Michael Mullan, MD, and his colleagues at the Roskamp Institute in Sarasota, Fl., collaborated with statisticians at the London School of Hygiene and Tropical Medicine to see if elevated levels of A? in the blood in first-degree relatives of Alzheimer?s patients are associated with risk factors for vascular disease. Recent studies have shown that vascular disease is a major risk factor for Alzheimer?s. They recruited 197 local study subjects from the Alzheimer?s Disease Anti-Inflammatory Prevention Trial, which included unaffected family members, as well as 98 community elders in Florida. They studied the association of amyloid beta levels in serum with risk factors for vascular disease, including total cholesterol, LDL, HDL, systolic blood pressure, diastolic blood pressure and serum creatinine. They also looked at medications prescribed for vascular disease or the risk factors associated with vascular disease.

A? in serum is used as a marker to predict A? accumulation in the brain, which is one of the key pathologies of Alzheimer?s. In this study, the scientists found A? levels were significantly higher in first-degree relatives of Alzheimer?s patients, as compared with the elder community controls. The scientists say they suspect this elevation may be ?indicative of increased amyloid beta production due to genetic and/or other risk factors.?

?These findings suggest that an increased risk of Alzheimer?s disease associated with family history may be mediated in part through the enrichment of individuals with vascular risk factors and may be reflective of pre-symptomatic Alzheimer?s disease pathology,? Dr. Mullan and his colleagues wrote.

In another stunning finding in the same issue of Molecular Medicine, scientists from Virginia Commonwealth University, Northwestern University, UCSF, UCLA, University of Pennsylvania, and University of North Carolina, identified a genetic signature for a hepatitis C virus-induced liver cancer, and different genetic handprints for cirrhosis caused by hepatitis C. They were able to use these genetic signatures to distinguish between pathological stages of liver cancer and early disease states, suggesting a way to diagnose this hepatocellular carcinoma earlier in the disease process.

Molecular Medicine is published by The Feinstein Institute for Medical Research, part of the North Shore-LIJ Health System. For more information on the study, visit http://www.molmed.org or contact Veronica J. Davis. Free podcasts from the latest issue of Molecular Medicine are also available on the journal?s web site and in iTunes.

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Related Carcinoma Press Releases

QuickMedical Announces Study Linking High Cholesterol Levels to Increased Risk for Developing Alzheimer’s Disease or Vascular Dementia


Issaquah, Wa (PRWEB) May 01, 2012

QuickMedical, a leading distributor of the CardioChek? cholesterol testing instrument for healthcare professionals, and the CardioChek? home cholesterol analyzer released a statement today hailing a new study by Kaiser Permanente. The study suggests that high cholesterol levels are a significant risk factor for developing dementia and Alzheimer’s Disease later in life.

The results of the study were published in the journal of Dementia & Geriatric Cognitive Disorders. The research study tracked 9,844 men and women for four decades, starting when the participants were between 40 and 45 years of age.

After controlling for weight, hypertension and diabetes, the researchers discovered a significant link between borderline-high cholesterol and dementia.

The participants in the study, who had high cholesterol, or a value of 240mg/dl or more, had a 66 percent greater risk of developing Alzheimer’s Disease later in life. People with borderline-high cholesterol, between 200 and 239, had a 25 percent spike in risk.

According to the American Heart Association, more than 106 million Americans reportedly have borderline-high cholesterol levels.

“With the availability of our CardioChek? cholesterol testing device for the healthcare professional and the CardioChek? analyzer for home use there is now a way for the public to know their cholesterol level number,” said Robert Huffstodt, President and CEO of Polymer Technology Systems. “The continued emergence of research findings such as these strongly reinforces the rationale for including cholesterol screenings as an integral part of healthcare preventative maintenance; not only with regards to heart disease and diabetes, but now with the risk of dementia and Alzheimer’s Disease.

The study concluded that people as young as 40 with borderline or high cholesterol levels are at increased risk for developing Alzheimer’s disease or vascular dementia. Previous studies have linked heart and brain health, but this study is the first to examine the association between borderline cholesterol levels and dementia.

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Vascular Disease Foundation Announces P.A.D. Coalition and Venous Disease

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Through the efforts of volunteers and the use of lectures, educational materials, free ultrasound testing and meetings with cardiovascular specialists, DTC brings the important message to the public that complications of cardiovascular disease can be
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"Million Hearts" initiative aims to reduce cardiovascular disease burden
"The treatment of heart disease and stroke accounts for about $ 1 of every $ 6 spent on health care in this country," Dr. Berwick said. "By shifting our focus from paying for how much care is provided to how to get the best health for Americans and
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SKMC to mark World Heart Day tomorrow
If an individual suspects a family member of having a heart attack or stroke, he/she should seek medical help immediately. Cardiovascular diseases are the world's largest killers, claiming 17.1 million lives a year. Risk factors for heart disease and
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Galantamine Hbr cures symptom alzheimers or vascular dementias symptoms

Galantamine Hbr cures mild to moderate symptom alzheimers or vascular dementias symptoms. Galantamine is produced from natural resources and a patented total synthesis process. It is an anti-alzheimer’s agent that comes under the class cholinesterase inhibitor. It is also an allosteric ligand at nicotinic acetylcholine receptors. It works by reducing the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. This process helps to cure symptoms of mild to moderate dementia in patients with Alzheimer disease.

 

Dementias symptoms include memory losses, impaired abstraction and planning, language and comprehension disturbances, poor judgment, impaired orientation ability, decreased attention and increased restlessness and behavioral changes and psychosis. Dementia is caused by gradual death of cells in the brain. It is sometimes accompanied by emotional disturbance and personality changes. The loss of mental ability interferes with normal day to day activities that last for more than six months. However, it is not present since birth and is not associated with a loss or alteration of consciousness.

 

Alzheimer’s disease or AD is the most common cause of dementia, followed by vascular dementias. AD is incurable and often proves fatal. However, there are several drugs that may slow its progression. Symptom alzheimers accounts for one-half to three-fourths of all cases for dementia. Vascular dementias are estimated to cause from 5% to 30% of all dementias. It usually progresses with stroke, infection and heart disease that can lead to death. It occurs from decrease in blood flow to the brain, most commonly due to a series of small strokes called multi-infarct dementia. Because of the usually sudden nature of its cause, the symptoms of vascular dementia tend to begin more abruptly than those of Alzheimer’s dementia. Its symptoms may progress stepwise with the occurrence of new strokes.

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Care for a person with dementia can be difficult and complex. In progressive dementias such as AD, the person may ultimately become completely dependent. Family members or others caring for a person with dementia often are subject to extreme stress. Since dementia usually progresses slowly, its diagnosing can be difficult in early stages. But, early diagnosis is important as the treatments can cure the early stages.

 

Diagnosis includes thorough physical examination and complete medical history. A variety of medical tests may require to determining the cause of dementia. The FDA has approved five prescription drugs for the treatment of AD symptoms. Four of these are used to treat mild to moderate AD. They are galantamine (Razadyne formerly known as Reminyl), rivastigmine (Exelon), donepezil (Aricept), and tacrine (Cognex).

 

Galantamines are available in the market under brand names Razadyne and Reminyl in the forms of tablets, capsules and oral solution. Galantamine hydrobromide under the name Reminyl was approved on February 2001 for use in mild to moderate dementia of the Alzheimer’s type. And under the name Razadyne, it was approved on August 28, 2008.

 

Galantamine has been used for decades in Eastern Europe and the USSR for various indications such as treatment of myasthenia, myopathy, and sensory and motor

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